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Kaufen Actoplus Met Online

  • €0,80
  • Verfügbarkeit: Lagernd
  • Wirkstoff: metformin
Actoplus Met dient der Behandlung von Typ2-Diabetes Mellitus.
Andere Namen von Actoplus Met: a   b   c   d   e   f   g   h   i   j   k   l   m   n   o   p   q   r   s   t   u   v   w   x   y   z  
Apo-Pioglitazone   Adpas   Actose   Actos Met   Adglim-M   Aglikem   Alexodiab   Amaryl m   Amaryl M Forte   Amaryl M SR   Amophage   Andibet   Anglucid   Anhe   Asegur   Asoformin   Asoformin-P   Asoride-M   Avandamet   Accord Metformin   Actomeg   ActoPlus met XR   Actos M   Actosmet   Adecco   Adimet   Adride-M   Agimfor   Aglumet   Aglurab   Amaryl Combi   Amaryl XM   Ammiformin   Andm   Anformin   Ankomin   Ansures   Ansures ER   Antigluco   Anxofin   Anxoken   Apo-Metformin   Aromet   Arrow Metformine HCL   Asformin   Austell-Metformin   Avamina   Azulix-MF   Accord Pioglitazone   Actose   Actozone   Adpas   Amaryl-P   Apo-Pioglitazone   Acpio   Actazone   Actos OD   Anxotos   Asenza Plus  
Alle anzeigen

500 mg
Produktname Pro Pille Pro Packung  
30 pillen €1,19 €35,78
60 pillen €0,98 €71,55 €58,67
90 pillen €0,91 €107,33 €81,57
120 pillen €0,87 €143,11 €104,46
180 pillen €0,83 €214,66 €150,25
270 pillen €0,81 €321,99 €218,95
360 pillen €0,80 €429,32 €287,62

Drug Name

Actoplus Met (Pioglitazone/Metformin) 

Drug Uses

Actoplus Met is used for treating type 2 diabetes. It is used along with diet and exercise. It may be used alone or with other antidiabetic medicines.
 
How to use

Use Actoplus Met as directed by your doctor. Check the label on the medicine for exact dosing instructions.
An extra patient leaflet is available with Actoplus Met . Talk to your pharmacist if you have questions about this information.
Take Actoplus Met by mouth with meals.
Take Actoplus Met on a regular schedule to get the most benefit from it. Taking Actoplus Met at the same times each day will help you remember to take it.
Continue to take Actoplus Met even if you feel well. Do not miss any doses.

Drug Class and Mechanism

Actoplus Met is a biguanide and thiazolidinedione antidiabetic combination. It works by decreasing the amount of sugar the liver produces and the intestines absorb. It also helps to make your body more sensitive to the insulin that you naturally produce. 

Missed Dose

If you miss a dose of Actoplus Met , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. 

Storage

Store this medicine at room temperature at 77 degrees F (25 degrees C) in a tightly-closed container, away from heat, moisture, and light. Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted.

Warnings/Precautions

Do NOT use Actoplus Met if: 
you are allergic to any ingredient in Actoplus Met
you have type 1 diabetes
you have moderate to severe heart failure
you have a severe infection, low blood oxygen levels, kidney or liver problems, or high blood ketone or acid levels (eg, diabetic ketoacidosis), or you are severely dehydrated
you have had a stroke or a recent heart attack, or you are in shock
you are 80 years old or more and have not had a kidney function test
you will be having surgery or certain lab procedures
you have a history of liver problems, including jaundice (yellowing of the skin or eyes), during therapy with a similar medicine called troglitazone

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Actoplus Met . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you have a history of heart problems (eg, heart failure), abnormal liver function tests, lung or breathing problems, thyroid problems, stomach or bowel problems (eg, paralysis, blockage), adrenal or pituitary problems, eye or vision problems (eg, macular degeneration), bladder cancer, or lactic acidosis
if you have fluid retention or swelling problems, vomiting, diarrhea, poor health or nutrition, low blood calcium or vitamin B12 levels, or anemia, or if you are dehydrated
if you have an infection, fever, recent injury, or moderate to severe burns
if you have a history of bone fracture, weak bones (eg, osteoporosis), or low calcium intake
if you drink alcohol or have a history of alcohol abuse
if you will be having surgery or certain lab procedures
if you take a beta-blocker (eg, propranolol)
Some MEDICINES MAY INTERACT with Actoplus Met . Tell your health care provider if you are taking any other medicines, especially any of the following:
Amiloride, cimetidine, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin because they may increase the risk of Actoplus Met 's side effects
Calcium channel blockers (eg, nifedipine), corticosteroids (eg, prednisone), diuretics (eg, furosemide, hydrochlorothiazide), estrogen, hormonal contraceptives (eg, birth control pills), insulin, isoniazid, nicotinic acid, oral antidiabetics (eg, glipizide), phenothiazines (eg, chlorpromazine), phenytoin, sympathomimetics (eg, albuterol, pseudoephedrine), or thyroid hormones (eg, levothyroxine) because the risk of high or low blood sugar may be increased
Gemfibrozil because it may increase the risk of Actoplus Met 's side effects
Rifampin because it may decrease Actoplus Met 's effectiveness, resulting in high blood sugar
Anticoagulants (eg, warfarin) because their effectiveness may be decreased or the risk of their side effects may be increased by Actoplus Met

Possible Side Effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome: 
Cold-like symptoms; diarrhea; headache; indigestion; mild weight gain; nausea; stomach upset.

Seek medical attention right away if any of these SEVERE side effects occur: 
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision or other vision changes; bone pain; chest pain or discomfort; dark urine; difficult or painful urination; dizziness or lightheadedness; fainting; fast or difficult breathing; feeling of being unusually cold; general feeling of being unwell; muscle pain or weakness; pale stools; persistent loss of appetite; severe or persistent headache, nausea, or vomiting; shortness of breath; slow or irregular heartbeat; sudden unexplained weight gain; swelling of the hands, ankles, or feet; unusual stomach pain or discomfort; unusual drowsiness; unusual tiredness or weakness; yellowing of the eyes or skin.

More Information

If you have any questions about Actoplus Met , please talk with your doctor, pharmacist, or other health care provider.
Actoplus Met is to be used only by the patient for whom it is prescribed. Do not share it with other people.
If your symptoms do not improve or if they become worse, check with your doctor.
If using Actoplus Met for an extended period of time, obtain refills before your supply runs out.

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More Common

  • Chest pain
  • decreased urine output
  • dilated neck veins
  • extreme fatigue
  • irregular breathing
  • irregular heartbeat
  • problems with teeth
  • swelling of the face, fingers, feet, or lower legs
  • tightness in the chest
  • trouble breathing
  • weight gain
  • Blurred vision or other changes in vision
  • cough
  • dry mouth
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of consciousness
  • muscle pain or soreness
  • problems with your teeth
  • runny or stuffy nose
  • sore throat
  • stomachache
  • sweating
  • unexplained weight loss

Less Common

  • Pain or swelling in the arms or legs without an injury
  • pale skin
  • swelling
  • trouble with breathing when active
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence Not Known

  • Dark urine
  • loss of appetite
  • nausea or vomiting
  • stomach pain
  • unexplained, rapid weight gain
  • yellow eyes or skin
Type Small Molecule
Accession Number DB01132  (APRD00653)
Groups Approved, Investigational
Synonyms
  • (+-)-5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
  • 5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
  • Pioglitazona
  • Pioglitazone
  • Pioglitazonum
UNII X4OV71U42S
CAS number 111025-46-8
Weight Average: 356.439
Monoisotopic: 356.119463206
Chemical Formula C19H20N2O3S
InChI
InChI=1S/C19H20N2O3S/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23)
IUPAC Name
5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
Protein binding

Pioglitazone is extensively protein bound (> 99%) in human serum, principally to serum albumin. Pioglitazone also binds to other serum proteins, but with lower affinity [Label].

Toxicity Not Available
Half life

The mean serum half-life of pioglitazone and its metabolites (M-III and M-IV) range from 3 to 7 hours and 16 to 24 hours, respectively [Label].

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